化合物APD 668
APD668(ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE)
CAS: 832714-46-2
化学式: C21H24FN5O5S
| 中文名 | APD668 |
| 英文名 | ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE |
| 别名 | 化合物APD 668 4-(1-(2-氟-4-(甲磺酰基)苯基)-1H-吡唑并[3,4-D]嘧啶-4-氧基)哌啶-1-羧酸异丙酯 异丙基 4-(1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-D]嘧啶-4-基氧基)哌啶-1-羧酸 |
| 英文别名 | APD668 APD 668 CS-1179 APD-668 ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE 4-[[1-(2-Fluoro-4-methylsulfonylphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]piperidine-1-carboxylic acid isopropyl ester 1-Piperidinecarboxylic acid,4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-, 1-methylethyl ester isopropyl 4-((1-(2-fluoro-4-(methylsulfonyl)phenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)piperidine-1-carboxylate APD668 APD668 ISOPROPYL 4-(1-(2-FLUORO-4-(METHYLSULFONYL)PHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLOXY)PIPERIDINE-1-CARBOXYLATE |
| CAS | 832714-46-2 |
| 化学式 | C21H24FN5O5S |
| 分子量 | 477.51 |
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 沸点 | 611.6±55.0 °C(Predicted) |
| 溶解度 | DMSO : 33.33 mg/mL (69.80 mM; 需要超声波);H2O: < 0.1 mg/mL (不溶) |
| 酸度系数 | 2.13±0.30(Predicted) |
| 存储条件 | -20°C |
| 体外研究 | APD668 increases adenylate cyclase activation in HEK293 cells transfected with human GPR119 in a concentration-dependent manner with an EC 50 of 23 nM. APD668 is highly bound to plasma proteins of male and female cynomolgus monkeys and humans (⩾99%), but is less extensively bound to male (93.0%) and female (96.6%) rats. |
| 体内研究 | APD668 (10-30 mg/kg; p.o. once daily for 8 weeks) significantly reduces blood glucose and glycated hemoglobin (HbA1c) levels, with no desensitization of the acute drug response. APD668 (1-10 mg/kg; a single p.o.) markedly reduces blood glucose levels during oral glucose tolerance test in a dose-dependent manner in mice. APD668 (0.08 mg/kg/min; i.v.) shows no effect during euglycemic condition, but significantly stimulates insulin release when blood glucose levels are raised to approximately 300 mg/dl in a hyperglycemic clamp model in the Sprague-Dawley rat. APD668 (p.o.) exhibits rapid to moderate absorption (t max ≤2 h) in mice, rats, and monkeys, but slower in dogs (t max =6 h), and moderate to good absolute oral bioavailability (44-79%) in mice, rats, and monkeys, but lower in dogs (22%). Animal Model: Male Zucker Diabetic Fatty (ZDF) rats (6 weeks old, 200-250 g) Dosage: 10, 30 mg/kg Administration: P.o. once daily for 8 weeks Result: Decreased the blood glucose and HbA1c levels at 30 mg/kg/day. Did not develop diabetes, whereas the vehicle treated rats did. |
化合物APD 668 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.094 ml | 10.471 ml | 20.942 ml |
| 5 mM | 0.419 ml | 2.094 ml | 4.188 ml |
| 10 mM | 0.209 ml | 1.047 ml | 2.094 ml |
| 5 mM | 0.042 ml | 0.209 ml | 0.419 ml |
最后更新：2024-01-02 23:10:35
化合物APD 668 - 简介
APD668是一种化学物质。
APD668主要是一种G蛋白偶联受体激动剂，作用于GLP-1受体和GIP受体，并且能够通过模拟胰岛素和血糖降低血糖水平。
制造APD668的方法多种多样，一种常见的方法是通过化学合成的方式制备。通过适当的合成路径，将合适的开始材料进行反应生成最终的产物APD668。
APD668属于实验室试剂，尚未被批准用于临床应用。在使用过程中，需要穿戴适当的防护设备，并按照正确的操作方法进行操作，避免接触到皮肤、眼睛或吸入其粉尘。
APD668主要是一种G蛋白偶联受体激动剂，作用于GLP-1受体和GIP受体，并且能够通过模拟胰岛素和血糖降低血糖水平。
制造APD668的方法多种多样，一种常见的方法是通过化学合成的方式制备。通过适当的合成路径，将合适的开始材料进行反应生成最终的产物APD668。
APD668属于实验室试剂，尚未被批准用于临床应用。在使用过程中，需要穿戴适当的防护设备，并按照正确的操作方法进行操作，避免接触到皮肤、眼睛或吸入其粉尘。
最后更新：2024-04-09 21:01:54
供应商列表
现货供应
产品名: 4-((1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-d]嘧啶-4-基)氧基)哌 去供应商网站查看 询盘CAS: 832714-46-2
产地: 中国上海
包装: 5mg
规格: 99%
价格: 1498.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：4-((1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-d]嘧啶-4-基)氧基)哌 英文名:APD668 CAS:832714-46-2 更多
现货供应
产品名: 4-((1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-d]嘧啶-4-基)氧基)哌 去供应商网站查看 询盘CAS: 832714-46-2
产地: 中国上海
包装: 5mg
规格: 99%
价格: 1498.00
库存: 现货
电话: 400-900-4166
手机: 18017137653
电子邮件: 3007523013@qq.com
QQ: 3007523013
微信: 18017137653
产品描述: 中文名：4-((1-(2-氟-4-(甲基磺酰基)苯基)-1H-吡唑并[3,4-d]嘧啶-4-基)氧基)哌 英文名:APD668 CAS:832714-46-2 更多
您刚刚浏览过
你知道吗？
微信搜索化工百科或扫描下方二维码，添加化工百科小程序，随时随地查信息！